A Rapid Bootstrap Algorithm for the RAxML Web Servers
Despite recent advances achieved by application of high-performance computing methods and novel algorithmic techniques to maximum likelihood (ML)-based inference programs, the m...
Publications
Explore 530 academic publications
Showing 12 of
530 publications
OrthoFinder: phylogenetic orthology inference for comparative genomics
Abstract Here, we present a major advance of the OrthoFinder method. This extends OrthoFinder’s high accuracy orthogroup inference to provide phylogenetic inference of orthologs...
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years before the diagnosis of AD dementia. This long “preclinical” phase of AD would provide ...
UniProt: the universal protein knowledgebase in 2021
Abstract The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional inf...
Power-law distributions in empirical data
Power-law distributions occur in many situations of scientific interest and have significant consequences for our understanding of natural and man-made phenomena. Unfortunately,...
Probability and Measure.
Probability. Measure. Integration. Random Variables and Expected Values. Convergence of Distributions. Derivatives and Conditional Probability. Stochastic Processes. Appendix. N...
The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest
Abstract Much of the complexity within cells arises from functional and regulatory interactions among proteins. The core of these interactions is increasingly known, but novel i...
Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
Background and Purpose— The purpose of these guidelines is to provide an up-to-date comprehensive set of recommendations in a single document for clinicians caring for adult pat...
Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions
On a shelf in the sunny, open‐plan office of Cochrane Australia in Melbourne, there's a large, white ring‐binder that, it's fair to say, hasn't been opened in a while. It's a pr...
Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction
BACKGROUND In patients with type 2 diabetes, inhibitors of sodium-glucose cotransporter 2 (SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through ...
‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*
Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus misleading, despite our best efforts to improve the de...