The complete sequence of a human genome
Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. Addr...
Publications
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789 publications
Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy
Among patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of less than 70 mg per deciliter (1.81 mmol per liter), there was no incremental clinical b...
High-Dose Atorvastatin after Stroke or Transient Ischemic Attack
In patients with recent stroke or TIA and without known coronary heart disease, 80 mg of atorvastatin per day reduced the overall incidence of strokes and of cardiovascular even...
RCP 8.5—A scenario of comparatively high greenhouse gas emissions
This paper summarizes the main characteristics of the RCP8.5 scenario. The RCP8.5 combines assumption about high population and relatively slow income growth with modest rates o...
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis
Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging...
Mental health problems and social media exposure during COVID-19 outbreak
Huge citizens expose to social media during a novel coronavirus disease (COVID-19) outbroke in Wuhan, China. We assess the prevalence of mental health problems and examine their...
Partial least squares for discrimination
Abstract Partial least squares (PLS) was not originally designed as a tool for statistical discrimination. In spite of this, applied scientists routinely use PLS for classificat...
Clues to the Pathogenesis of Familial Colorectal Cancer
A predisposition to colorectal cancer is shown to be linked to markers on chromosome 2 in some families. Molecular features of "familial" cancers were compared with those of spo...
RCV1: A New Benchmark Collection for Text Categorization Research
Reuters Corpus Volume I (RCV1) is an archive of over 800,000 manually categorized newswire stories recently made available by Reuters, Ltd. for research purposes. Use of this da...