Alison Goate

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

We found that autosomal dominant Alzheimer's disease was associated with a series of pathophysiological changes over decades in CSF biochemical markers of Alzheimer's disease, b...

Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer’s Disease

Longitudinal cerebrospinal fluid biomarker analyses reveal decreases in neuronal injury markers in later stages of autosomal-dominant Alzheimer’s disease.

Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease

Significance Beta-amyloid plaque accumulation, glucose hypometabolism, and neuronal atrophy are hallmarks of Alzheimer’s disease. However, the regional ordering of these biomark...

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease

Patients with Alzheimer's disease vary in their ability to sustain cognitive abilities in the presence of brain pathology. A major open question is which brain mechanisms may su...

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

A mutation in Alzheimerʼs disease destroying a splice acceptor site in the presenilin-1 gene

A series of mutations has been reported in the presenilin-1 (PS-1) gene which cause early onset Alzheimer's disease (AD). The mutations reported to date have encoded missense mu...

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder