Interleukin-10 and the Interleukin-10 Receptor
Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with d...
Publications
6 shownEosinophil differentiation factor also has B-cell growth factor activity: proposed name interleukin 4.
A mouse lymphokine that stimulates the production of functional eosinophils in liquid bone marrow cultures has recently been described [Sanderson, C.J., Warren, D.J. & Strat...
IL-10 inhibits cytokine production by activated macrophages
Abstract IL-10 inhibits the ability of macrophage but not B cell APC to stimulate cytokine synthesis by Th1 T cell clones. In this study we have examined the direct effects of I...
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
Abstract Murine IL-10 (cytokine synthesis inhibitory factor) inhibits cytokine production by Th1 cell clones when they are activated under conditions requiring the presence of A...
B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.
We have previously shown that dendritic cells isolated after overnight culture, which can express B7 and are potent stimulators of naive T cell proliferation, are relatively poo...
The molecular basis of T helper 1 and T helper 2 cell differentiation
Cytokines such as interleukin 12 (IL-12) and IL-4 are dominant factors in driving the development of T helper 1 (Th1) and Th2 cells, respectively, through specific signalling pa...
Frequent Co-Authors
Researcher Info
- h-index
- 6
- Publications
- 6
- Citations
- 12,284
- Institution
- National Institute for Medical Research
External Links
Identifiers
- ORCID
- 0000-0001-9845-6134
Impact Metrics
h-index
6
h-index: Number of publications with at least h citations each.