Chris C. A. Spencer

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermitten...

Class II HLA interactions modulate genetic risk for multiple sclerosis

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 p...

Identification of loci associated with schizophrenia by genome-wide association and follow-up

FINEMAP: efficient variable selection using summary data from genome-wide association studies

Abstract Motivation: The goal of fine-mapping in genomic regions associated with complex diseases and traits is to identify causal variants that point to molecular mechanisms be...