Christopher M. Dobson

The formation of spherulites by amyloid fibrils of bovine insulin

Bovine insulin has long been known to self-assemble in vitro into amyloid fibrils. We have observed a further higher-order self-association of the protein into spherical structu...

Protein Misfolding, Functional Amyloid, and Human Disease

Peptides or proteins convert under some conditions from their soluble forms into highly ordered fibrillar aggregates. Such transitions can give rise to pathological conditions r...

Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

Simultaneous determination of protein structure and dynamics

Analysis of .vphi. and .chi.1 torsion angles for hen lysozyme in solution from proton NMR spin-spin coupling constants

Three-bond 3JHN alpha coupling constants have been determined for 106 residues and 3J alpha beta coupling constants have been measured for 57 residues of the 129-residue protein...