Curtis C. Harris

Conformation-dependent phosphorylation of p53

Phosphorylation of the p53 tumor suppressor protein is known to modulate its functions. Using bacterially produced glutathione S -transferase (GST)-p53 fusion protein and baculo...

p53 Mutations in Human Cancers

Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are common in diverse types of human cancer. The p53 mutational spectrum differs among cancers ...

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

Frequent mutation of the p53 gene in human esophageal cancer.

Sequence alterations in the p53 gene have been detected in human tumors of the brain, breast, lung, and colon, and it has been proposed that p53 mutations spanning a major porti...

Human pulmonary alveolar macrophages metabolise benzo(a)pyrene to proximate and ultimate mutagens