Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers
Tyrosine kinases (TKs) are central regulators of signaling pathways that control differentiation, transcription, cell cycle progression, apoptosis, motility, and invasion ( [1][...
Publications
7 shownEpitope Landscape in Breast and Colorectal Cancer
Abstract The finding that individual cancers contain many mutant genes not present in normal tissues has prompted considerable interest in the cancer epitope landscape. To furth...
The Consensus Coding Sequences of Human Breast and Colorectal Cancers
The elucidation of the human genome sequence has made it possible to identify genetic alterations in cancers in unprecedented detail. To begin a systematic analysis of such alte...
The Genomic Landscapes of Human Breast and Colorectal Cancers
Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we isolated DNA ...
Somatic mutations in the chromatin remodeling gene <i>ARID1A</i> occur in several tumor types
Mutations in the chromatin remodeling gene ARID1A have recently been identified in the majority of ovarian clear cell carcinomas (OCCCs). To determine the prevalence of mutation...
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determin...
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
There are currently few therapeutic options for patients with pancreatic cancer, and new insights into the pathogenesis of this lethal disease are urgently needed. Toward this e...
Frequent Co-Authors
Researcher Info
- h-index
- 7
- Publications
- 7
- Citations
- 16,863
- Institution
- Howard Hughes Medical Institute
External Links
Identifiers
- ORCID
- 0000-0002-8775-3501
Impact Metrics
h-index
7
h-index: Number of publications with at least h citations each.