Enhancing Gene Targeting with Designed Zinc Finger Nucleases
Gene targeting—the process of gene replacement by homologous recombination—is a very useful but typically inefficient technique ( [1][1] ). A general method for improving the ef...
Publications
3 shownRecombination Induced by Triple-Helix-Targeted DNA Damage in Mammalian Cells
Gene therapy has been hindered by the low frequency of homologous recombination in mammalian cells. To stimulate recombination, we investigated the use of triple-helix-forming o...
Targeted Chromosomal Cleavage and Mutagenesis in Drosophila Using Zinc-Finger Nucleases
Abstract Zinc-finger nucleases (ZFNs) are hybrids between a nonspecific DNA-cleavage domain and a DNA-binding domain composed of Cys2His2 zinc fingers. Because zinc fingers can ...
Frequent Co-Authors
Researcher Info
- h-index
- 3
- Publications
- 3
- Citations
- 1,755
- Institution
- University of Utah
External Links
Identifiers
- ORCID
- 0000-0002-3241-3331
Impact Metrics
h-index
3
h-index: Number of publications with at least h citations each.