Enhancing Gene Targeting with Designed Zinc Finger Nucleases

Marina Bibikova; Kelly J. Beumer; Jonathan K. Trautman; Dana Carroll

doi:10.1126/science.1079512

Abstract

Gene targeting—the process of gene replacement by homologous recombination—is a very useful but typically inefficient technique ( [1][1] ). A general method for improving the efficiency of gene targeting would be valuable in many circumstances, as would the extension of this genetic tool to a

Keywords

Zinc finger nucleaseZinc fingerGenome editingZincGeneComputational biologyBiologyChemistryCRISPRGeneticsTranscription factor

Affiliated Institutions

University of Utah US

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Publication Info

Year: 2003
Type: article
Volume: 300
Issue: 5620
Pages: 764-764
Citations: 807
Access: Closed

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APA Style

                            
                                
                                    Marina Bibikova, 
                                
                                    Kelly J. Beumer, 
                                
                                    Jonathan K. Trautman
                                
                                et al.
                            
                            (2003). 
                            Enhancing Gene Targeting with Designed Zinc Finger Nucleases. 
                            Science
                            , 300
                            (5620)
                            , 764-764.
                            https://doi.org/10.1126/science.1079512
                        

Identifiers

DOI: 10.1126/science.1079512