Mechanism of activation of protein kinase B by insulin and IGF-1.
Insulin activated endogenous protein kinase B alpha (also known as RAC/Akt kinase) activity 12-fold in L6 myotubes, while after transfection into 293 cells PKBalpha was activate...
Publications
8 shownCharacterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
Protein kinase B (PKB), also known as c-Akt, is activated rapidly when mammalian cells are stimulated with insulin and growth factors, and much of the current interest in this e...
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
Protein kinase B (PKB), and the p70 and p90 ribosomal S6 kinases (p70 S6 kinase and p90 Rsk, respectively), are activated by phosphorylation of two residues, one in the 'T-loop'...
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
Protein kinase B (PKB) is activated by phosphorylation of Thr308 and of Ser473. Thr308 is phosphorylated by the 3-phosphoinositide-dependent protein kinase-1 (PDK1) but the iden...
The PI3K–PDK1 connection: more than just a road to PKB
Phosphoinositide 3-kinases (PI3Ks) generate specific inositol lipids that have been implicated in the regulation of cell growth, proliferation, survival, differentiation and cyt...
Role of Translocation in the Activation and Function of Protein Kinase B
We have investigated the role of subcellular localization in the regulation of protein kinase B (PKB) activation. The myristoylation/palmitylation motif from the Lck tyrosine ki...
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase
The substrate specificity of protein kinase‐Bα (PKBα, also known as RAC kinase or Akt) was investigated using synthetic peptide substrates related to the sequence surrounding th...
PKB/Akt
The serine/threonine protein kinase PKB (also known as Akt) is thought to be a key mediator of signal transduction processes. The identification of PKB substrates and the role P...
Frequent Co-Authors
Researcher Info
- h-index
- 8
- Publications
- 8
- Citations
- 11,064
- Institution
- MRC Protein Phosphorylation and Ubiquitylation Unit
External Links
Identifiers
- ORCID
- 0000-0002-2140-9185
Impact Metrics
h-index
8
h-index: Number of publications with at least h citations each.