George M. Church

Gene synthesis by circular assembly amplification

RNA-Guided Human Genome Engineering via Cas9

Genome Editing Clustered regularly interspaced short palindromic repeats (CRISPR) function as part of an adaptive immune system in a range of prokaryotes: Invading phage and pla...

Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips

A Robust Approach to Identifying Tissue-Specific Gene Expression Regulatory Variants Using Personalized Human Induced Pluripotent Stem Cells

Normal variation in gene expression due to regulatory polymorphisms is often masked by biological and experimental noise. In addition, some regulatory polymorphisms may become a...

Genomic sequencing.

Unique DNA sequences can be determined directly from mouse genomic DNA. A denaturing gel separates by size mixtures of unlabeled DNA fragments from complete restriction and part...

Human Genome Sequencing Using Unchained Base Reads on Self-Assembling DNA Nanoarrays

Toward $1000 Genomes The ability to generate human genome sequence data that is complete, accurate, and inexpensive is a necessary prerequisite to perform genome-wide disease as...

Multiplex Sequencing of 1.5 Mb of the <i>Mycobacterium leprae</i> Genome

The nucleotide sequence of 1.5 Mb of genomic DNA from Mycobacterium leprae was determined using computer-assisted multiplex sequencing technology. This brings the 2.8-Mb M. lepr...