James E. Herndon

Phase I Trial of Temozolomide Plus <i>O</i>⁶-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

Purpose We conducted a two-phase clinical trial in patients with progressive malignant glioma (MG). The first phase of this trial was designed to determine the dose of O 6 -BG e...

Phase I Trial of Carmustine Plus O6-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

PURPOSE: The major mechanism of resistance to alkylnitrosourea therapy involves the DNA repair protein O 6 -alkylguanine-DNA alkyltransferase (AGT), which removes chloroethylati...

The impact of docetaxel, estramustine, and low dose hydrocortisone on the quality of life of men with hormone refractory prostate cancer and their partners: A feasibility study

Identifying Predictive Factors for Radiation Necrosis vs. Local Recurrence in Biopsy-Proven Enlarging Lesions Post-Stereotactic Radiosurgery for Brain Metastases

Lay Summary Cancers that spread to the brain are often treated with focused radiation. After treatment, brain scans sometimes show that the treated area continues to grow, which...