Jianyi Yang

The I-TASSER Suite: protein structure and function prediction

Protein–ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment

Abstract Motivation: Identification of protein–ligand binding sites is critical to protein function annotation and drug discovery. However, there is no method that could generat...

Improved protein structure prediction using predicted interresidue orientations

The prediction of interresidue contacts and distances from coevolutionary data using deep learning has considerably advanced protein structure prediction. Here, we build on thes...

BioLiP: a semi-manually curated database for biologically relevant ligand–protein interactions

BioLiP (http://zhanglab.ccmb.med.umich.edu/BioLiP/) is a semi-manually curated database for biologically relevant ligand-protein interactions. Establishing interactions between ...

COACH-D: improved protein–ligand binding sites prediction with refined ligand-binding poses through molecular docking

The identification of protein-ligand binding sites is critical to protein function annotation and drug discovery. The consensus algorithm COACH developed by us represents one of...