Karen O’Rourke - Researcher Profile

Publications

3 shown

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

Arul M. Chinnaiyan , Karen O’Rourke , Brian R. Lane +1 more

Previous genetic studies of the nematode Caenorhabditis elegans identified three important components of the cell death machinery. CED-3 and CED-4 function to kill cells, wherea...

1997 Science 635 citations

Cryopyrin activates the inflammasome in response to toxins and ATP

Sanjeev Mariathasan , David S. Weiss , Kim Newton +7 more

A crucial part of the innate immune response is the assembly of the inflammasome, a cytosolic complex of proteins that activates caspase-1 to process the proinflammatory cytokin...

2006 Nature 2985 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

Marta Muzio , Arul M. Chinnaiyan , Frank Kischkel +11 more

1996 Cell 3044 citations

Frequent Co-Authors

Researcher Info

h-index: 3
Publications: 3
Citations: 6,664
Institution: University of Michigan

External Links

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Impact Metrics

h-index 3

h-index: Number of publications with at least h citations each.