Michael Brudno

Savant: genome browser for high-throughput sequencing data

Abstract Motivation: The advent of high-throughput sequencing (HTS) technologies has made it affordable to sequence many individuals' genomes. Simultaneously the computational a...

ProbCons: Probabilistic consistency-based multiple sequence alignment

To study gene evolution across a wide range of organisms, biologists need accurate tools for multiple sequence alignment of protein families. Obtaining accurate alignments, howe...

LAGAN and Multi-LAGAN: Efficient Tools for Large-Scale Multiple Alignment of Genomic DNA

To compare entire genomes from different species, biologists increasingly need alignment methods that are efficient enough to handle long sequences, and accurate enough to corre...

Development of an artificial intelligence based virtual tool for measuring distances during image-guided surgery