Peter J. Richardson

Baricitinib as potential treatment for 2019-nCoV acute respiratory disease

COVID-19: combining antiviral and anti-inflammatory treatments

Figure 5 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma

<p>Clinical experience of combined vandetanib and everolimus in a 7-year-old girl with ACVR1-mutant DIPG (case 1). <b>A,</b> Timeline summarizing the clinical ...

Table 1 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma

<p>Demographics of three children with newly diagnosed <i>ACVR1</i>-mutant DIPG treated with vandetanib and mTOR inhibitors upfront or at relapse</p>

Table 2 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma

<p>Summary of toxicities graded as per Common Terminology Criteria for Adverse Events version 4.03 related to vandetanib and/or mTOR inhibitors in three children with newl...

Supplementary Figures S1-S3 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma

<p>Supplementary Figures S1-S3</p>

Figure 1 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma

<p>Schema for AI-based identification of a repurposed drug combination strategy for <i>ACVR1</i>-mutant DIPG. The BenevolentAI knowledge graph was employed to ...

Figure 4 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma

<p>Efficacy of combined vandetanib and everolimus <i>in vivo</i>. <b>A,</b> Tolerability in NOD.SCID mice exposed to daily oral treatment with the ...

Figure 3 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma

<p>Synergy of combined vandetanib and everolimus <i>in vitro</i>. <b>A,</b> Cell viability matrix for <i>ACVR1</i><sup>R206H</...

Figure 2 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma

<p>Validation of vandetanib as an ACVR1 inhibitor and everolimus as a P-gp inhibitor. <b>A,</b> Kinome selectivity map for vandetanib at 10 μmol/L, with red ci...