Amyloid Aggregates, Presenilins, and Alzheimer's Disease
The cooperative action of three proteases is required to process the APP protein (695-770 amino acids) into small β-amyloid peptides (Aβ, 40-42 amino acids). Aβ aggregates are f...
Publications
2 shownHuman presenilin‐1, but not familial Alzheimer’s disease (FAD) mutants, facilitate <i>Caenorhabditis elegans</i> Notch signalling independently of proteolytic processing
The majority of cases with familial Alzheimer’s disease (FAD) are linked to mutations of the presenilin (PS) genes. These genes show considerable sequence similarity to the sel‐...
Frequent Co-Authors
Researcher Info
- h-index
- 2
- Publications
- 2
- Citations
- 244
- Institution
- Ludwig-Maximilians-Universität München
External Links
Identifiers
- ORCID
- 0000-0002-1632-4777
Impact Metrics
h-index
2
h-index: Number of publications with at least h citations each.