Richard A. Flavell

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

Programmed cell death (apoptosis) is a prominent feature of the development of the immune and nervous systems. The identification of the Caenorhabditis elegans cell death gene, ...

TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

Mammalian Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs). Although TLRs are clearly involved in the detection ...

A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria

Toll-like receptors (TLRs) recognize molecular patterns displayed by microorganisms, and their subsequent activation leads to the transcription of appropriate host-defense genes...

Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus

DNA methylation and the regulation of globin gene expression

The polarization of immune cells in the tumour environment by TGFβ