Yiran Guo

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants

The diploid genome sequence of an Asian individual

Here we present the first diploid genome sequence of an Asian individual. The genome was sequenced to 36-fold average coverage using massively parallel sequencing technology. We...

Design of association studies with pooled or un‐pooled next‐generation sequencing data

Abstract Most common hereditary diseases in humans are complex and multifactorial. Large‐scale genome‐wide association studies based on SNP genotyping have only identified a sma...

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness¹, affecting 0.9-4% of women and 0.3% of men^2-4, with tw...