Cancer Research UK Scotland Institute

Cellular Senescence: Defining a Path Forward

Mitochondria as multifaceted regulators of cell death

Crypt stem cells as the cells-of-origin of intestinal cancer

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

Cancer organoids to model therapy response Cancer organoids are miniature, three-dimensional cell culture models that can be made from primary patient tumors and studied in the ...

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

The availability of p53 knockout mice generated by gene targeting has enabled us to investigate the functional role of the p53 tumor suppressor gene in initiation, promotion, an...

Oncogene Activation in Chemical Carcinogenesis

Mutational specificity of alkylating agents and the influence of DNA repair

Abstract Alkylating treatments predominantly induce G: C = > A: T transitions, consistent with the predicted significance of the miscoding potential of the O 6 ‐alG lesion. H...