Framingham Heart Study

Prediction of Coronary Heart Disease Using Risk Factor Categories

Background —The objective of this study was to examine the association of Joint National Committee (JNC-V) blood pressure and National Cholesterol Education Program (NCEP) chole...

The mutational constraint spectrum quantified from variation in 141,456 humans

Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences of gene disruption: genes that are crucial for the f...

Worldwide Epidemiology of Atrial Fibrillation

Background— The global burden of atrial fibrillation (AF) is unknown. Methods and Results— We systematically reviewed population-based studies of AF published from 1980 to 2010 ...

The Natural History of Congestive Heart Failure: The Framingham Study

The natural history of congestive heart failure was studied over a 16-year period in 5192 persons initially free of the disease. Over this period, overt evidence of congestive h...

Vitamin D Deficiency and Risk of Cardiovascular Disease

Background— Vitamin D receptors have a broad tissue distribution that includes vascular smooth muscle, endothelium, and cardiomyocytes. A growing body of evidence suggests that ...

Cardiovascular disease risk profiles

This article presents prediction equations for several cardiovascular disease endpoints, which are based on measurements of several known risk factors. Subjects (n = 5573) were ...

Lifetime Risk for Development of Atrial Fibrillation

Background— Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity and mortality, but lifetime risk for AF has not been estimated...

Is Pulse Pressure Useful in Predicting Risk for Coronary Heart Disease?

Background —Current definitions of hypertension are based on levels of systolic blood pressure (SBP) and diastolic blood pressure (DBP), but not on pulse pressure (PP). We exami...

Does the Relation of Blood Pressure to Coronary Heart Disease Risk Change With Aging?

Background —We examined the relative importance of diastolic (DBP), systolic (SBP) and pulse pressure (PP) as predictors of coronary heart disease (CHD) risk in different age gr...

Common variants at 30 loci contribute to polygenic dyslipidemia