Institute of Genetics and Cancer

Discovery and refinement of loci associated with lipid levels

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for c...

A reference panel of 64,976 haplotypes for genotype imputation

The Human Cell Atlas

The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the ...

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Common variants associated with plasma triglycerides and risk for coronary artery disease

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coro...

Nuclear organization of the genome and the potential for gene regulation

The spatial organization of human chromosomes within the nuclei of normal and emerin-mutant cells

To fully understand genome function, the linear genome map must be integrated with a spatial map of chromosomes in the nucleus. Distinct nuclear addresses for a few human chromo...

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pr...

Abundant Pleiotropy in Human Complex Diseases and Traits