Instituto de Salud Carlos III

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19

In this prospective meta-analysis of clinical trials of critically ill patients with COVID-19, administration of systemic corticosteroids, compared with usual care or placebo, w...

Quantifying prion disease penetrance using large population control cohorts

Large genomic reference data sets reveal a spectrum of pathogenicity in the prion protein gene and provide genetic validation for a therapeutic strategy in prion disease.

Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease

Atherosclerosis is the underlying reason for nearly all causes of coronary artery disease and peripheral arterial disease and many cases of stroke. Atherosclerosis is a systemic...

Introduction of High-sensitivity Troponin Assays: Impact on Myocardial Infarction Incidence and Prognosis

Trends in the incidence of diagnosed diabetes: a multicountry analysis of aggregate data from 22 million diagnoses in high-income and middle-income settings

Estimating the burden of disease in one Swiss canton: what do disability adjusted life years (DALY) tell us?

Some of the most important problems identified-depression, osteoarthritis and alcohol abuse-would have been overlooked in an analysis based solely on mortality data. The most st...