Jinan University

TBtools-II: A “one for all, all for one” bioinformatics platform for biological big-data mining

Techniques for extraction and isolation of natural products: a comprehensive review

Coronavirus infections and immune responses

Abstract Coronaviruses (CoVs) are by far the largest group of known positive‐sense RNA viruses having an extensive range of natural hosts. In the past few decades, newly evolved...

KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis

Abstract Gene set enrichment (GSE) analysis plays an essential role in extracting biological insight from genome-scale experiments. ORA (overrepresentation analysis), FCS (funct...

The cytokine storm and COVID‐19

Abstract Coronavirus disease 2019 (COVID‐19), which began in Wuhan, China, in December 2019, has caused a large global pandemic and poses a serious threat to public health. More...

Macrophages in immunoregulation and therapeutics

Abstract Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host defense against many ...

Targeting PI3K/Akt signal transduction for cancer therapy

The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various cellular processes and is aberrantly activated in cancers, contributing to the occurrence an...

T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice

ABSTRACT A dysregulated innate immune response and exuberant cytokine/chemokine expression are believed to be critical factors in the pathogenesis of severe acute respiratory sy...