Johns Hopkins Medicine

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

Multilineage Potential of Adult Human Mesenchymal Stem Cells

Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to ...

A global reference for human genetic variation

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of revising the 1984 criteria for Alzheimer's disease (AD) dementia. The workgr...

FLASH: fast length adjustment of short reads to improve genome assemblies

Abstract Motivation: Next-generation sequencing technologies generate very large numbers of short reads. Even with very deep genome coverage, short read lengths cause problems i...

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

The human reference genome represents only a small number of individuals, which limits its usefulness for genotyping. We present a method named HISAT2 (hierarchical indexing for...

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

A genetic model for colorectal tumorigenesis