Lunenfeld-Tanenbaum Research Institute

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a med...

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

The endothelial cell-specific vascular endothelial growth factor (VEGF) and its cellular receptors Flt-1 and Flk-1 have been implicated in the formation of the embryonic vascula...

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

A Proteome-Scale Map of the Human Interactome Network

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles

Genome-wide transcript profiling was used to monitor signal transduction during yeast pheromone response. Genetic manipulations allowed analysis of changes in gene expression un...

<i>flk-1</i>, an <i>flt</i>-related receptor tyrosine kinase is an early marker for endothelial cell precursors

ABSTRACT We have used RT-PCR to screen pluripotent murine embryonic stem cells to identify receptor tyrosine kinases (RTKs) potentially involved in the determination or differen...

FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

Abstract The adaptation of CRISPR/SpCas9 technology to mammalian cell lines is transforming the study of human functional genomics. Pooled libraries of CRISPR guide RNAs (gRNAs)...

Wilms Tumor Suppressor WTX Negatively Regulates WNT/ß-Catenin Signaling

Aberrant WNT signal transduction is involved in many diseases. In colorectal cancer and melanoma, mutational disruption of proteins involved in the degradation of β-catenin, the...