McGovern Institute for Brain Research

fMRIPrep: a robust preprocessing pipeline for functional MRI

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

Taking CRISPR technology further CRISPR techniques are allowing the development of technologies for nucleic acid detection (see the Perspective by Chertow). Taking advantages of...

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

MicroRNA Expression in Zebrafish Embryonic Development

MicroRNAs (miRNAs) are small noncoding RNAs, about 21 nucleotides in length, that can regulate gene expression by base-pairing to partially complementary mRNAs. Regulation by mi...

SHERLOCK: nucleic acid detection with CRISPR nucleases

Rapid detection of nucleic acids is integral to applications in clinical diagnostics and biotechnology. We have recently established a CRISPR-based diagnostic platform that comb...

Microarray analysis of microRNA expression in the developing mammalian brain

Abstract Background MicroRNAs are a large new class of tiny regulatory RNAs found in nematodes, plants, insects and mammals. MicroRNAs are thought to act as post-transcriptional...

Cortical Folding Patterns and Predicting Cytoarchitecture

The human cerebral cortex is made up of a mosaic of structural areas, frequently referred to as Brodmann areas (BAs). Despite the widespread use of cortical folding patterns to ...

A transcription activator-like effector toolbox for genome engineering