Medical College of Wisconsin

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

Functional connectivity in the motor cortex of resting human brain using echo‐planar mri

Abstract An MRI time course of 512 echo‐planar images (EPI) in resting human brain obtained every 250 ms reveals fluctuations in signal intensity in each pixel that have a physi...

Integrated genomic analyses of ovarian carcinoma

The Immune Landscape of Cancer

We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identi...

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis. Recent studies in animal models have indicated that TNF-alpha plays an important role ...

Toward discovery science of human brain function

Although it is being successfully implemented for exploration of the genome, discovery science has eluded the functional neuroimaging community. The core challenge remains the d...

Relation of Body Fat Distribution to Metabolic Complications of Obesity*

The importance of body fat distribution as a predictor of metabolic aberrations was evaluated in 9 nonobese and 25 obese, apparently healthy women. Plasma glucose and insulin le...

Processing strategies for time‐course data sets in functional mri of the human brain

Abstract Image processing strategies for functional magnetic resonance imaging (FMRI) data sets acquired using a gradient‐recalled echo‐planar imaging sequence are considered. T...

Guidelines for investigating causality of sequence variants in human disease

Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers