Regeneron (United States)

Vascular-specific growth factors and blood vessel formation

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

Angiogenesis is thought to depend on a precise balance of positive and negative regulation. Angiopoietin-1 (Ang1) is an angiogenic factor that signals through the endothelial ce...

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

Among patients who had a previous acute coronary syndrome and who were receiving high-intensity statin therapy, the risk of recurrent ischemic cardiovascular events was lower am...

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

In this interim analysis, the REGN-COV2 antibody cocktail reduced viral load, with a greater effect in patients whose immune response had not yet been initiated or who had a hig...

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

An antibody cocktail against SARS-CoV-2 There is an urgent focus on antibodies that target the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral spike and preve...

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

In a small group of patients with hereditary ATTR amyloidosis with polyneuropathy, administration of NTLA-2001 was associated with only mild adverse events and led to decreases ...

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

Brain‐Derived Neurotrophic Factor Protects Dopamine Neurons Against 6‐Hydroxydopamine and <i>N</i>‐Methyl‐4‐Phenylpyridinium Ion Toxicity: Involvement of the Glutathione System

Abstract Brain‐derived neurotrophic factor (BDNF) has recently been shown to enhance the survival of dopamine neurons in cultures derived from the embryonic rat mesencephalon. W...