Royal Edinburgh Hospital

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

Cortical grey matter reductions associated with treatment-resistant chronic unipolar depression

Background The aetiology of treatment-resistant major depression is little understood; its apparent intractability may reflect brain abnormality. Method Magnetic resonance image...

Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

Abstract Imputing genotypes from reference panels created by whole-genome sequencing (WGS) provides a cost-effective strategy for augmenting the single-nucleotide polymorphism (...

The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability

A new scale for measuring mania

Synopsis A modified version of the Manic State Rating Scale comprising 28 items with a glossary has been tested on 16 manic patients. The scale has satisfactory inter-rater reli...