A Computer Program for Aligning a cDNA Sequence with a Genomic DNA Sequence

Abstract

We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation.

Keywords

BiologySequence (biology)GeneticsAlignment-free sequence analysisgenomic DNAComputational biologyIntronDNA sequencingSequence logoSequence analysisSequence alignmentDNAGeneConsensus sequenceBase sequencePeptide sequence

Affiliated Institutions

Pennsylvania State University US

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Publication Info

Year: 1998
Type: article
Volume: 8
Issue: 9
Pages: 967-974
Citations: 727
Access: Closed

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Cite This

APA Style

                            
                                
                                    Liliana Florea, 
                                
                                    George Hartzell, 
                                
                                    Zheng Zhang
                                
                                et al.
                            
                            (1998). 
                            A Computer Program for Aligning a cDNA Sequence with a Genomic DNA Sequence. 
                            Genome Research
                            , 8
                            (9)
                            , 967-974.
                            https://doi.org/10.1101/gr.8.9.967
                        

Identifiers

DOI: 10.1101/gr.8.9.967