Abstract
Summary The exact test for neutrality based on the Ewens sampling distribution described previously (Slatkin, 1994) is not correct. The problem is that the test as described is based on the probability of the ordered configuration of numbers of alleles, while it should be based on the probability of the unordered configuration. The correctly implemented exact test leads to results that are similar to those from the homozygosity test proposed by Watterson (1977) for relatively small sample sizes but can still differ substantially for larger sample sizes. Programs to perform the exact test are available from the author.
Keywords
Exact testSampling (signal processing)StatisticsMathematicsTest (biology)Distribution (mathematics)Sample (material)Sample size determinationComputer scienceAlgorithmApplied mathematicsBiologyPhysicsMathematical analysisEcology
MeSH Terms
Computer SimulationGene FrequencyModelsGeneticSampling Studies
Affiliated Institutions
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Publication Info
- Year
- 1996
- Type
- article
- Volume
- 68
- Issue
- 3
- Pages
- 259-260
- Citations
- 197
- Access
- Closed
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Cite This
Montgomery Slatkin
(1996).
A correction to the exact test based on the Ewens sampling distribution.
Genetics Research
, 68
(3)
, 259-260.
https://doi.org/10.1017/s0016672300034236
Identifiers
- DOI
- 10.1017/s0016672300034236
- PMID
- 9062082