Abstract
This communication describes a new and highly practical Pd(II)-catalyzed method for the regio- and chemoselective oxidative functionalization of arenes and alkanes. Carbon-hydrogen bonds of substrates that contain a variety of directing groups (e.g., pyridine, azobenzene, pyrazole, and imine derivatives) are selectively transformed into esters, ethers, and aryl-halides under mild conditions. The scope of this reaction in terms of substrate, directing group, and oxidant is described, and a preliminary catalytic cycle is proposed.
Keywords
ChemistrySurface modificationCatalysisArylImineCatalytic cycleCombinatorial chemistrySubstrate (aquarium)AzobenzenePyridineHydrogen peroxideHydrogen bondFunctional groupAryl halidePyrazoleOxidative phosphorylationOrganic chemistryMoleculePalladium
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Publication Info
- Year
- 2004
- Type
- article
- Volume
- 126
- Issue
- 8
- Pages
- 2300-2301
- Citations
- 1041
- Access
- Closed
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Cite This
Allison R. Dick,
Kami L. Hull,
Melanie S. Sanford
(2004).
A Highly Selective Catalytic Method for the Oxidative Functionalization of C−H Bonds.
Journal of the American Chemical Society
, 126
(8)
, 2300-2301.
https://doi.org/10.1021/ja031543m
Identifiers
- DOI
- 10.1021/ja031543m