Abstract

Endotoxin (lipopolysaccharide, LPS) has been found to act on all three cell types of the immune system, thymus-derived (T-) cells, bone marrow-derived (B-) cells, and macrophages. LPS is mitogenic for B-lymphocytes and activates them to release a chemotactic lymphokine. Macrophage activation appears to be mediated by macrophage-activating factor, another lymphokine released from B-cells. In addition, LPS acts synergistically with phytohemagglutinin to initiate division of purified T-lymphocytes. All these phenomena are mediated by the lipid A moiety of LPS. The role of lymphoid cells in mediating the lethal effects of LPS have also been investigated. The adoptive transfer of spleen cells from LPS-responsive mice (C3H/HeN) to LPS-resistant but histocompatible mice (C3H/HeJ) rendered the LPS-resistant mice significantly more susceptible to LPS-induced lethality. These findings suggest that spleen cells play an essential role in mediating the lethal effects of LPS in vivo.

Keywords

LipopolysaccharideLymphokineSpleenLipid AAdoptive cell transferMacrophageImmune systemBiologyImmunologyBone marrowIn vitroT cellBiochemistry

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Publication Info

Year
1977
Type
article
Volume
136
Issue
Supplement 1
Pages
S239-S245
Citations
23
Access
Closed

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Cite This

David L. Rosenstreich, L. Michael Glade, Stephan E. Mergenhagen (1977). Action of Endotoxin on Lymphoid Cells. The Journal of Infectious Diseases , 136 (Supplement 1) , S239-S245. https://doi.org/10.1093/infdis/136.supplement.s239

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DOI
10.1093/infdis/136.supplement.s239