Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2

Connie Celum , Anna Wald , Jairam R. Lingappa , Connie Celum , Anna Wald , Jairam R. Lingappa , Amalia Magaret , R.S. Wang , Nelly Mugo , Andrew Mujugira , Jared M. Baeten , James I. Mullins , James P. Hughes , Elizabeth A. Bukusi , Craig R. Cohen , Elly Katabira , Allan Ronald , James Kiarie , Carey Farquhar , Grace John Stewart , Joseph Makhema , Max Essex , Edwin Were , K H Fife , Guy de Bruyn , Glenda Gray , James McIntyre , Rachel Manongi , Saidi Kapiga , David Coetzee , Susan Allen , Mubiana Inambao , Kayitesi Kayitenkore , Etienne Karita , William Kanweka , Sinéad Delany , Helen Rees , Bellington Vwalika , Wendy Stevens , Mical S. Campbell , Katherine K. Thomas , Robert W. Coombs , Rhoda Ashley Morrow , William L. H. Whittington , M. Juliana McElrath , Linda Barnes , Renée Ridzon , Lawrence Corey
2010 New England Journal of Medicine 521 citations

Abstract

Daily acyclovir therapy did not reduce the risk of transmission of HIV-1, despite a reduction in plasma HIV-1 RNA of 0.25 log(10) copies per milliliter and a 73% reduction in the occurrence of genital ulcers due to HSV-2. (ClinicalTrials.gov number, NCT00194519.)

Keywords

Herpes simplex virusHSL and HSVMedicineVirologyTransmission (telecommunications)Human immunodeficiency virus (HIV)Genital herpesVirusHerpes GenitalisSex organImmunologyBiology

MeSH Terms

AIDS-Related Opportunistic InfectionsAcyclovirAdolescentAdultAntiviral AgentsCD4 Lymphocyte CountFemaleFollow-Up StudiesHIV InfectionsHIV-1Herpes GenitalisHerpesvirus 2HumanHumansIntention to Treat AnalysisKaplan-Meier EstimateMalePatient CompliancePregnancyRNAViralUnsafe SexYoung Adult

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Publication Info

Year
2010
Type
letter
Volume
362
Issue
5
Pages
427-439
Citations
521
Access
Closed

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Cite This

Connie Celum, Anna Wald, Jairam R. Lingappa et al. (2010). Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2. New England Journal of Medicine , 362 (5) , 427-439. https://doi.org/10.1056/nejmoa0904849

Identifiers

DOI
10.1056/nejmoa0904849
PMID
20089951
PMCID
PMC2838503

Data Quality

Data completeness: 86%