Keywords
Affiliated Institutions
Related Publications
Narrative Review: Antiretroviral Therapy to Prevent the Sexual Transmission of HIV-1
Antiretroviral therapy (ART) has prolonged and improved the lives of persons infected with HIV. Theoretically, it can also be used to prevent the transmission of HIV. The pharma...
Importance of Surrogate Markers in Evaluation of Antiviral Therapy for HIV Infection
CONVENTIONAL randomized clinical trials of new treatments usually rely on clinical end points that directly show the effect of the new treatment on outcomes such as quality or l...
Surrogate Markers in AIDS: Where Are We? Where Are We Going?
Editorials1 April 1992Surrogate Markers in AIDS: Where Are We? Where Are We Going?Stephen W. Lagakos, PhD, Daniel F. Hoth, MDStephen W. Lagakos, PhD, Daniel F. Hoth, MDAuthor, A...
The extent of non-adherence in a large AIDS clinical trial using plasma dideoxynucleoside concentrations as a marker
Various non-adherence behaviors were observed, including patterns of underdosing and taking non-prescribed drugs. Non-adherence was moderate but uniform amongst the treatment gr...
Changes in Plasma HIV RNA Levels and CD4+ Lymphocyte Counts Predict Both Response to Antiretroviral Therapy and Therapeutic Failure
An adequate virologic response after initiation of antiretroviral therapy seems to require a decrease in plasma HIV RNA level of at least 0.5 log10 copies/mL that is sustained f...
Publication Info
- Year
- 1997
- Type
- review
- Volume
- 50
- Issue
- 4
- Pages
- 385-391
- Citations
- 309
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1016/s0895-4356(97)00041-3