Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer

2021 New England Journal of Medicine 1,584 citations

Abstract

Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longer among those who received nivolumab adjuvant therapy than among those who received placebo. (Funded by Bristol Myers Squibb and Ono Pharmaceutical; CheckMate 577 ClinicalTrials.gov number, NCT02743494.).

Keywords

Gastroesophageal JunctionNivolumabMedicineEsophageal cancerAdjuvantChemoradiotherapyInternal medicineOncologyEsophagectomyCancerGastroenterologyAdenocarcinomaImmunotherapy

MeSH Terms

AdenocarcinomaAdultAgedAged80 and overB7-H1 AntigenCarcinomaSquamous CellChemoradiotherapyAdjuvantChemotherapyAdjuvantDisease-Free SurvivalDouble-Blind MethodEsophageal NeoplasmsEsophagogastric JunctionFemaleHumansImmune Checkpoint InhibitorsIntention to Treat AnalysisKaplan-Meier EstimateMaleMiddle AgedNeoadjuvant TherapyNivolumabStomach Neoplasms

Affiliated Institutions

Related Publications

Publication Info

Year
2021
Type
article
Volume
384
Issue
13
Pages
1191-1203
Citations
1584
Access
Closed

Social Impact

Social media, news, blog, policy document mentions

Citation Metrics

1584
OpenAlex
69
Influential
1395
CrossRef

Cite This

Ronan J. Kelly, Jaffer A. Ajani, Jarosław Kużdżał et al. (2021). Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer. New England Journal of Medicine , 384 (13) , 1191-1203. https://doi.org/10.1056/nejmoa2032125

Identifiers

DOI
10.1056/nejmoa2032125
PMID
33789008

Data Quality

Data completeness: 90%