Abstract
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence of extracellular β-amyloid deposition as neuritic plaques and intracellular accumulation of hyperphosphorylated tau as neurofibrillary tangles remains the primary neuropathologic criteria for AD diagnosis. However, a number of recent fundamental discoveries highlight important pathological roles for other critical cellular and molecular processes. Despite this, no disease-modifying treatment currently exists, and numerous phase 3 clinical trials have failed to demonstrate benefits. Here, we review recent advances in our understanding of AD pathobiology and discuss current treatment strategies, highlighting recent clinical trials and opportunities for developing future disease-modifying therapies.
Keywords
DiseaseSenile plaquesClinical trialBiologyAlzheimer's diseaseNeurosciencePathologicalAmyloid (mycology)Biochemistry of Alzheimer's diseaseBioinformaticsPathologyAmyloid precursor proteinMedicine
MeSH Terms
Alzheimer DiseaseAlzheimer VaccinesAmyloid beta-PeptidesAnimalsApolipoproteins EClinical Trials as TopicHumansMicePlaqueAmyloidtau Proteins
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Publication Info
- Year
- 2019
- Type
- review
- Volume
- 179
- Issue
- 2
- Pages
- 312-339
- Citations
- 2865
- Access
- Closed
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Cite This
Justin M. Long,
David M. Holtzman
(2019).
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.
Cell
, 179
(2)
, 312-339.
https://doi.org/10.1016/j.cell.2019.09.001
Identifiers
- DOI
- 10.1016/j.cell.2019.09.001
- PMID
- 31564456
- PMCID
- PMC6778042