An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos

Janine A Davis; Satoshi Naruse; Hua Chen; Chris Eckman; Steven G. Younkin; Donald L. Price; David Borchelt; Sangram S. Sisodia; Philip C. Wong

doi:10.1016/s0896-6273(00)80998-8

Keywords

DiseaseEmbryoAlzheimer's diseaseBiologyGeneticsPsychologyPresenilinNeuroscienceDevelopmental psychologyMedicinePathology

Affiliated Institutions

Related Publications

Time Course of the Development of Alzheimer-like Pathology in the Doubly Transgenic PS1+APP Mouse

Marcia N. Gordon , Leigh A. Holcomb , Paul Jantzen +7 more

2002 Experimental Neurology 246 citations

A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17

Ian R. Mackenzie , Matthew Baker , Gemma West +14 more

Over 30 different mutations have now been identified in MAPt that cause frontotemporal dementia (FTD). However, there are several families with FTD that show definite linkage to...

2006 Brain 104 citations

Hereditary dysphasic disinhibition dementia A frontotemporal dementia linked to 17 q21‐‐22

Corinne Lendon , Timothy Lynch , Joanne Norton +11 more

Several dementias have been linked to the same region and have been termed frontotemporal dementia with parkinsonism linked to chromosome 17. These disorders may represent pheno...

1998 Neurology 143 citations

Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

Eric M. Reiman , Kewei Chen , Gene E. Alexander +5 more

Fluorodeoxyglucose positron emission tomography (PET) studies have found that patients with Alzheimer's dementia (AD) have abnormally low rates of cerebral glucose metabolism in...

2003 Proceedings of the National Academy o... 965 citations

Enriched environments, experience-dependent plasticity and disorders of the nervous system

Jess Nithianantharajah , Anthony J. Hannan

2006 Nature reviews. Neuroscience 1723 citations

Publication Info

Year: 1998
Type: article
Volume: 20
Issue: 3
Pages: 603-609
Citations: 131
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

131

OpenAlex

Cite This

APA Style

                            
                                
                                    Janine A Davis, 
                                
                                    Satoshi Naruse, 
                                
                                    Hua Chen
                                
                                et al.
                            
                            (1998). 
                            An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos. 
                            Neuron
                            , 20
                            (3)
                            , 603-609.
                            https://doi.org/10.1016/s0896-6273(00)80998-8
                        

Identifiers

DOI: 10.1016/s0896-6273(00)80998-8