Abstract
Many biochemically diverse proteins can give rise to amyloid fibrils; however, they are all accompanied by P component and glucosaminoglycans. With antibodies specific to apolipoprotein E (apo E) we used immunohistochemical techniques to test for the presence of this protein in both cerebral and systemic amyloid. We found apo E immunoreactivity in all tested types of cerebral and systemic amyloid. In amyloid deposits apo E P, component and glucosaminoglycans may be acting as 'pathological molecular chaperones'. The latter we define as a group of unrelated proteins that induce beta-pleated conformation in amyloidogenic polypeptides.
Keywords
Amyloid (mycology)PathologicalApolipoprotein EImmunohistochemistrySerum amyloid P componentApolipoprotein BAmyloidosisBiochemistry of Alzheimer's diseaseAmyloid fibrilP3 peptidePathologyBiologyChemistryBiochemistryAlzheimer's diseaseAmyloid βMedicineAmyloid precursor proteinImmunologyInflammationDiseaseCholesterolC-reactive protein
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Publication Info
- Year
- 1992
- Type
- article
- Volume
- 135
- Issue
- 2
- Pages
- 235-238
- Citations
- 799
- Access
- Closed
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Cite This
Thomas Wısnıewskı,
Blas Frangione
(1992).
Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid.
Neuroscience Letters
, 135
(2)
, 235-238.
https://doi.org/10.1016/0304-3940(92)90444-c
Identifiers
- DOI
- 10.1016/0304-3940(92)90444-c