Basal Insulin and Cardiovascular and Other Outcomes in Dysglycemia

Origin Trial Investigators; Hertzel C. Gerstein; Jackie Bosch; Gilles R. Dagenais; Rafael Dı́az; Hye Jung Jung; Aldo P. Maggioni; Janice Pogue; Jeffrey L. Probstfield; Ambady Ramachandran; Matthew C Riddle; Lars Rydén; Salim Yusuf

doi:10.1056/nejmoa1203858

Abstract

When used to target normal fasting plasma glucose levels for more than 6 years, insulin glargine had a neutral effect on cardiovascular outcomes and cancers. Although it reduced new-onset diabetes, insulin glargine also increased hypoglycemia and modestly increased weight. (Funded by Sanofi; ORIGIN ClinicalTrials.gov number, NCT00069784.).

Keywords

Basal insulinBasal (medicine)InsulinInternal medicineMedicineEndocrinologyDiabetes mellitusType 2 diabetes

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Publication Info

Year: 2012
Type: article
Volume: 367
Issue: 4
Pages: 319-328
Citations: 1600
Access: Closed

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APA Style

                            
                                
                                    Origin Trial Investigators, 
                                
                                    Hertzel C. Gerstein, 
                                
                                    Jackie Bosch
                                
                                et al.
                            
                            (2012). 
                            Basal Insulin and Cardiovascular and Other Outcomes in Dysglycemia. 
                            New England Journal of Medicine
                            , 367
                            (4)
                            , 319-328.
                            https://doi.org/10.1056/nejmoa1203858
                        

Identifiers

DOI: 10.1056/nejmoa1203858