Blood pressure from mid‐ to late life and risk of incident dementia

Abstract

Elevated blood pressure during midlife, persistence of elevated blood pressure into late life, and, among nonhypertensives, a steep decline in blood pressure during mid- to late life were associated with an increased dementia risk in a community-based cohort. Our data highlight the potential sustained cognitive benefits of lower blood pressures in midlife but also suggest that declining blood pressure in older adults with prehypertension or normotension, but not in those with hypertension, may be a risk marker for dementia.

Keywords

Blood pressureDementiaHazard ratioMedicineFramingham Heart StudyProportional hazards modelConfidence intervalInternal medicineCardiologyFramingham Risk ScoreDisease

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Publication Info

Year: 2017
Type: article
Volume: 89
Issue: 24
Pages: 2447-2454
Citations: 260
Access: Closed

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APA Style

                            
                                
                                    Emer R. McGrath, 
                                
                                    Alexa S. Beiser, 
                                
                                    Charles DeCarli
                                
                                et al.
                            
                            (2017). 
                            Blood pressure from mid‐ to late life and risk of incident dementia. 
                            Neurology
                            , 89
                            (24)
                            , 2447-2454.
                            https://doi.org/10.1212/wnl.0000000000004741
                        

Identifiers

DOI: 10.1212/wnl.0000000000004741