Abstract

There are three distinct enolase isoenzymes in brain; neuron-specific enolase (NSE), formerly referred to as neuron-specific protein, which is specifically localized in neurons, a nonneuronal enolase (NNE), and a third hybrid form. Light microscopy with immunocytochemical techniques has permitted localization of non-neuronal enolase. The NNE is located in glial cells with no staining of endothelial cells or neurons. Thus, NSE and NNE can be used as specific metabolic markers for neurons and glial cells, respectively.

Keywords

EnolaseBiologyIsozymeNeuronImmunocytochemistryNeurogliaCell biologyNeuroscienceImmunohistochemistryBiochemistryEnzymeCentral nervous systemImmunologyEndocrinology

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Year
1978
Type
article
Volume
199
Issue
4326
Pages
313-315
Citations
464
Access
Closed

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Donald E. Schmechel, Paul J. Marangos, Athanasios P. Zis et al. (1978). Brain Enolases as Specific Markers of Neuronal and Glial Cells. Science , 199 (4326) , 313-315. https://doi.org/10.1126/science.339349

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DOI
10.1126/science.339349