Abstract
By the early 1980s, epidemiologists had identified many important causes of cancer. They had also proposed the 'multi-stage' model of cancer, although none of the hypothesized events in human carcinogenesis had then been identified. The remarkable advances in cell and molecular biology over the past two decades have transformed the scope and methods of cancer epidemiology. There have been a few new discoveries based purely on traditional methods, and many long-suspected minor risks have been estimated more precisely. But modern epidemiological studies often depend on genetic, biochemical or viral assays that had not been developed 20 years ago.
Keywords
EpidemiologyCancerEpidemiology of cancerGenetic epidemiologyMolecular epidemiologyBiologyMedicineGeneticsPathologyBreast cancer
MeSH Terms
Body WeightCarcinogensEnvironmentalDietGenetic Predisposition to DiseaseHormonesHumansImmunosuppression TherapyIncidenceNeoplasmsOccupational ExposurePolymorphismGeneticReproductionSmoking
Affiliated Institutions
Related Publications
Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
Abstract Observational epidemiological studies suffer from many potential biases, from confounding and from reverse causation, and this limits their ability to robustly identify...
Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Nasopharyngeal Aspirates and Swine/Avian-Origin Influenza A Subtypes in Culture Isolates
This study evaluated a new multiplex kit, Luminex NxTAG Respiratory Pathogen Panel, for respiratory pathogens and compared it with xTAG RVP Fast v2 and FilmArray Respiratory Pan...
The UK Biobank resource with deep phenotyping and genomic data
Abstract The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom...
Estimation of individual admixture: Analytical and study design considerations
Abstract The genome of an admixed individual represents a mixture of alleles from different ancestries. In the United States, the two largest minority groups, African‐Americans ...
Expression of bacterial genes in plant cells.
Chimeric bacterial genes conferring resistance to aminoglycoside antibiotics have been inserted into the Agrobacterium tumefaciens tumor-inducing (Ti) plasmid and introduced int...
Publication Info
- Year
- 2001
- Type
- review
- Volume
- 411
- Issue
- 6835
- Pages
- 390-395
- Citations
- 677
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
677
OpenAlex
19
Influential
Cite This
Julian Peto
(2001).
Cancer epidemiology in the last century and the next decade.
Nature
, 411
(6835)
, 390-395.
https://doi.org/10.1038/35077256
Identifiers
- DOI
- 10.1038/35077256
- PMID
- 11357148