Institute of Cancer Research

Mutations of the BRAF gene in human cancer

Signatures of mutational processes in human cancer

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

A recent report that 93 per cent of invasive cervical cancers worldwide contain human papillomavirus (HPV) may be an underestimate, due to sample inadequacy or integration event...

The cancer genome

Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective

The demonstration that more than 20 different genital HPV types are associated with cervical cancer has important implications for cervical cancer-prevention strategies that inc...

DNA methylation-based classification of central nervous system tumours

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

Tumour necrosis factor and cancer

The landscape of cancer genes and mutational processes in breast cancer

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations, confer clonal selective advantage on cancer cells and are causally implicated in oncog...

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

Many individuals with multiple or large colorectal adenomas or early-onset colorectal cancer (CRC) have no detectable germline mutations in the known cancer predisposition genes...