CDD/SPARCLE: the conserved domain database in 2020

Abstract

Abstract As NLM’s Conserved Domain Database (CDD) enters its 20th year of operations as a publicly available resource, CDD curation staff continues to develop hierarchical classifications of widely distributed protein domain families, and to record conserved sites associated with molecular function, so that they can be mapped onto user queries in support of hypothesis-driven biomolecular research. CDD offers both an archive of pre-computed domain annotations as well as live search services for both single protein or nucleotide queries and larger sets of protein query sequences. CDD staff has continued to characterize protein families via conserved domain architectures and has built up a significant corpus of curated domain architectures in support of naming bacterial proteins in RefSeq. These architecture definitions are available via SPARCLE, the Subfamily Protein Architecture Labeling Engine. CDD can be accessed at https://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml.

Keywords

RefSeqBiologyDomain (mathematical analysis)Protein domainArchitecture domainConserved sequenceFunction (biology)Computational biologyDatabaseComputer scienceGeneticsBase sequenceProgramming languageGenomeSoftwareSoftware architecture

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Publication Info

Year: 2019
Type: article
Volume: 48
Issue: D1
Pages: D265-D268
Citations: 3101
Access: Closed

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APA Style

                            
                                
                                    Shennan Lu, 
                                
                                    Jiyao Wang, 
                                
                                    Farideh Chitsaz
                                
                                et al.
                            
                            (2019). 
                            CDD/SPARCLE: the conserved domain database in 2020. 
                            Nucleic Acids Research
                            , 48
                            (D1)
                            , D265-D268.
                            https://doi.org/10.1093/nar/gkz991
                        

Identifiers

DOI: 10.1093/nar/gkz991