Conditions for the induction of delayed-type hypersensitivity (DTH) in mice to serum proteins ware studied. DTH to bovine serum albumin (BSA) was induced by a subcutaneous immunization with the antigen emulsified with Freund’s complete adjuvant. The level of DTH was found to be dependent not only on the dose of antigen but also on the amount of mycobacteria included in the adjuvant. DTH to other serum proteins was also induced under the same sensitizing conditions as for BSA. Success in the adoptive transfer with lymphoid cells and suppressive effect of anti-thymocyte serum indicated that delayed-type reaction studied here was the manifestation of cell-mediated immunity.
The Ly and Ia phenotypes of T lymphocytes involved in different functions were characterized by the use of specific antisera. T cells responsible for delayed-type hypersensitivi...
In mice, primary footpad swelling after local infection with lymphocytic choriomeningitis virus (LCMV) and delayed-type hypersensitivity (DTH) adoptively transferred by LCMV imm...
The in vivo administration of certain monoclonal antibodies (mAbs) against the adhesion receptor, CD44, into normal mice induces both a modulation of CD44 from the surface of pe...
Abstract The immunologic consequences resulting from thymectomy in adult lifewere investigated. Primary humoral responses were not diminished shortlyafter adult thymectomy, as j...
We investigated the role of antigen-presenting cells in early interferon (IFN)-γ production in normal and recombinase activating gene 2–deficient (Rag-2−/−) mice in response to ...
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