Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression.

Mathew A. Vadas; J. F. A. P. Miller; Ian F. C. McKenzie; Stanley E. Chism; F W Shen; Edward A. Boyse; Jennifer R. Gamble; Alison Whitelaw

doi:10.1084/jem.144.1.10

Abstract

The Ly and Ia phenotypes of T lymphocytes involved in different functions were characterized by the use of specific antisera. T cells responsible for delayed-type hypersensitivity (DTH) and for helper functions were found to be Ly-1+,2- in contrast to cytotoxic T cells and T cells responsible for suppression of antibody responses which were Ly-1-,2+. Unlike some primed helper cells, T cells involved in DTH were Ia-. Suppressor cells in the system were Ia+.

Keywords

Cytotoxic T cellPhenotypeAntigenImmunologyBiologyDelayed hypersensitivityAntibodySuppressorMolecular biologyInterleukin 21AntiserumAntigen-presenting cellT cellImmune systemIn vitroCD8GeneticsGene

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Publication Info

Year: 1976
Type: article
Volume: 144
Issue: 1
Pages: 10-19
Citations: 207
Access: Closed

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APA Style

                            
                                
                                    Mathew A. Vadas, 
                                
                                    J. F. A. P. Miller, 
                                
                                    Ian F. C. McKenzie
                                
                                et al.
                            
                            (1976). 
                            Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression.. 
                            The Journal of Experimental Medicine
                            , 144
                            (1)
                            , 10-19.
                            https://doi.org/10.1084/jem.144.1.10
                        

Identifiers

DOI: 10.1084/jem.144.1.10