Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin

Caleb A. Lareau; Ya-Chieh Hsu; Aviv Regev; Jason D. Buenrostro; Sai Ma; Bing Zhang; Lindsay M. LaFave; Andrew Earl; Zachary Chiang; Yan Hu; Jiarui Ding; Alison Brack; Vinay K. Kartha; Tristan Tay; Travis Law

doi:10.1016/j.cell.2020.09.056

Keywords

ChromatinBiologyChIA-PETBivalent chromatinCellular differentiationGene expressionChIP-sequencingRegulation of gene expressionComputational biologyChromatin remodelingCell fate determinationEnhancerCell biologyGeneGene expression profilingGeneticsHistoneTranscription factor

Affiliated Institutions

Related Publications

Chromatin accessibility and the regulatory epigenome

Sandy Klemm , Zohar Shipony , William J. Greenleaf

Physical access to DNA is a highly dynamic property of chromatin that plays an essential role in establishing and maintaining cellular identity. The organization of accessible c...

2019 Nature Reviews Genetics 1797 citations

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

Cole Trapnell , Davide Cacchiarelli , Jonna Grimsby +7 more

Defining the transcriptional dynamics of a temporal process such as cell differentiation is challenging owing to the high variability in gene expression between individual cells...

2014 Nature Biotechnology 7128 citations

Genome-wide map of regulatory interactions in the human genome

Nastaran Heidari , Douglas H. Phanstiel , Chao He +5 more

Increasing evidence suggests that interactions between regulatory genomic elements play an important role in regulating gene expression. We generated a genome-wide interaction m...

2014 Genome Research 292 citations

A high-resolution map of the three-dimensional chromatin interactome in human cells

Fulai Jin , Yan Li , Jesse R. Dixon +7 more

2013 Nature 1249 citations

Interaction Between Transcription Regulatory Regions of Prolactin Chromatin

Katherine Cullen , Michael P. Kladde , Mark A. Seyfred

The regulation of transcription requires complex interactions between proteins bound to DNA sequences that are often separated by hundreds of base pairs. As demonstrated by a nu...

1993 Science 202 citations

Publication Info

Year: 2020
Type: article
Volume: 183
Issue: 4
Pages: 1103-1116.e20
Citations: 1061
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1061

OpenAlex

Cite This

APA Style

                            
                                
                                    Caleb A. Lareau, 
                                
                                    Ya-Chieh Hsu, 
                                
                                    Aviv Regev
                                
                                et al.
                            
                            (2020). 
                            Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin. 
                            Cell
                            , 183
                            (4)
                            , 1103-1116.e20.
                            https://doi.org/10.1016/j.cell.2020.09.056
                        

Identifiers

DOI: 10.1016/j.cell.2020.09.056